Causality assessment, severity and preventability of adverse drug reactions due to first-line antitubercular agents

TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions one of the major concerns for management TB. The current study has been conducted identifying causality assessment, severity as well preventability first-line anti-tubercular agents. All diagnosed patients tuberculosis attending and chest department tertiary care hospital western India received Anti-TB drugs over 6 months enrolled in study. Demographic details, suspected drugs/groups, assessment were analyzed from reported ADR (adverse reaction) forms. Throughout research period months, 500 drugs. Among them, (10%) 50 developed 121 reactions. According to WHO scale, 66 (54.54%) ADRs classified ‘probable’ 53 (43.8%) ‘possible’. More than half (31, 62%) mild on scale while most definitely (34, 68%) preventable per scale. Gastrointestinal system affected (54, 47.62%) followed by dermatological disorders (26, 23.01%) Liver biliary (20, 16.52%). Isoniazid (46, 38%) Rifampicin (40, 33%) cause antitubercular agents ADRs. are concern patient compliance. Patient education, intensive reporting, can be helpful improve outcome therapy.